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  1. Home
  2. MLB Picks
  3. Houston Astros vs Pittsburgh Pirates
Thu 6:40 PM ET
Houston Astros logo
Houston
Astros8
F. Valdez LHP
versus
Pittsburgh Pirates logo
Pittsburgh
Pirates2
M. Keller RHP
Final
Team123456789T
Houston Astros0004002028
Pittsburgh Pirates00101000

Houston Astros vs Pittsburgh Pirates Betting Picks & Predictions

Game time: June 5, 2025 at 6:40 PM ET

Venue: PNC Park — Pittsburgh, Pennsylvania

Article updated Jun 5, 6:01 PM EDT

Published by SportsJaw Editorial Team

This content discusses the upcoming final game of a three-game early week interleague series between the Houston Astros and the Pittsburgh Pirates at PNC Park. The Astros won

Game outlook

This content discusses the upcoming final game of a three-game early week interleague series between the Houston Astros and the Pittsburgh Pirates at PNC Park. The Astros won the opening game of the series, and the article explores whether they will prevail again on getaway day or if the Pirates can secure a win at home in the finale. The starting pitchers for the game are Framber Valdez for the Astros and Mitch Keller for the Pirates. Houston is currently the favorite in the betting odds, opening at -145 with the current line at Houston -144. This prediction was made before the conclusion of the middle game of the set. Major League Baseball analysis is provided.

Betting Odds

Moneyline: Astros -144 | Pirates +126

Spread: Astros -1.5 (+120) | Pirates +1.5 (-137)

Total: Over/Under 7.5 (-110)

Based on the moneyline, the implied probability that Houston will win straight-up is 59%.

Houston Astros

The Houston Astros continued their winning streak by defeating the Pittsburgh Pirates in the opening game of their series. The Astros currently hold a half-game lead over the Mariners in the AL West with a record of 81-81. Christian Walker and Isaac Paredes each hit home runs in the game, with Lance McCullers Jr. earning the win on the mound. Framber Valdez is expected to start the next game for the Astros, coming off a strong performance in his last outing. Houston is ranked 16th in power rankings with a solid defense and offense, holding a record of 33-28 on the season.

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MLB · Houston Astros at Pittsburgh Pirates

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Pittsburgh Pirates Analysis

Despite another strong performance from their ace, the Pittsburgh Pirates suffered their second consecutive loss and fifth in the last eight games on Tuesday night, falling to the bottom of the NL Central with a record of 82-80. The team struggled to generate offense, mustering only four hits and failing to capitalize with runners in scoring position. Pitcher Mitch Keller will take the mound in the next game, looking to improve on his 1-7 record this season. The Pirates have a power ranking of 15 and are ranked 29th for offense, scoring an average of 3.23 runs per game. In their last three matchups, Houston went 1-2 against Pittsburgh.

Keller Struggles Despite Strong Performance, Valdez Leading Astros to Success

Keller has faced challenges this season, going 0-5 in six starts during the month of May despite maintaining a 3.50 ERA, a 1.20 WHIP, and averaging six innings per outing. Although he delivered five quality starts during this period, the Pirates provided minimal run support with only 10 runs scored in total across all six starts. In contrast, Valdez has achieved success with a three-game winning streak and a recent complete game against Tampa Bay. The Astros secured a victory in the opening game against Skenes on Tuesday. It is anticipated that Valdez will continue his strong performance and lead the Astros to another win on getaway day.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#HoustonAstros#PittsburghPirates

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Astros vs Pirates archived game preview contains historical odds and availability that may no longer be current. View history of past Astros vs Pirates matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Houston Astros-145 → -140Moved
  • Moneyline · Pittsburgh Pirates+129 → +123Moved
  • Spread · Houston Astros-1.5 (+115) → -1.5 (+120)Moved
  • Spread · Pittsburgh Pirates+1.5 (-135) → +1.5 (-140)Moved
  • Total · Over7.5 (-110) → 7.5 (-110)Unchanged
  • Total · Under7.5 (-110) → 7.5 (-110)Unchanged

ATS and O/U trends

Houston Astros
81-81 matchup record · 5-5-0 ATS · 3-6-1 O/U
Last 10 completed games on file
Pittsburgh Pirates
82-80 matchup record · 7-3-0 ATS · 4-6-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-06-05T22:01:09.577Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2025-06-04Houston Astros 0 · Pittsburgh Pirates 3
  • 2025-06-03Houston Astros 3 · Pittsburgh Pirates 0
Final result

Matchup pick recap

Houston Astros defeated Pittsburgh Pirates 8-2

Houston Astros defeated Pittsburgh Pirates 8-2 on June 5, 2025, a 6-run decision in the series. Houston Astros' strongest period was the 4th inning, when it outscored its opponent 4-0. Against SportsJaw's recorded Houston Astros -1.5 (+120) spread, Houston Astros covered, while the 10 combined runs finished over the recorded total of 7.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • EXCELent Sports PicksRunline · Pittsburgh Pirates +1.5 (-134)Loss