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MLB MatchupsFri 6:40 PM ET
Chicago
Cubs
C. Holmes RHP
VS
Cincinnati
Reds
C. Burns RHP
MLB · CHC at CIN

Your Picks on Cubs vs Reds

Picks close 15 minutes before game time (ET)
Runline
Moneyline
Total

Chicago vs Cincinnati consensus picks

CHC42%
58%CIN
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Stevec_Atx

12-7 record · 63.2% wins
Last 30 days · MLB

$1,000 pick on the total

Chicago Cubs vs Cincinnati Reds Predictions: Clay Holmes vs Chase Burns

Game time: September 18, 2026 at 6:40 PM ET

Article updated Sep 18, 10:57 AM EDT

By SportsJaw Editorial Team

The Cubs have the stronger season profile, but uneven results from Clay Holmes and Chase Burns’ previous outing against Chicago keep confidence low.

Chicago’s season numbers support the price

The Chicago Cubs visit the Cincinnati Reds on September 18 in this 2026 MLB matchup, with Clay Holmes and Chase Burns listed as the starters. SportsJaw prices Chicago at -126 on the moneyline and Cincinnati at +113.

Chicago’s clearest advantage comes from its overall production. The Cubs are 85-68, averaging 5.34 runs scored and 4.41 allowed per game. Cincinnati is 71-82, averaging 4.14 scored and 5.14 allowed. Those figures favor Chicago on both sides of the scoring ledger, while the Reds have lost eight of their last 10 games. They support a Cubs lean without establishing a precise probability of winning.

The starters leave room for doubt

Holmes allowed eight earned runs in 4 1/3 innings at Miami on September 6. Against Pittsburgh on September 12, he surrendered three runs, two earned, over 5 2/3 innings, with five hits, four walks and six strikeouts. That improvement matters, but the walks and preceding rough start make a strong pitching-edge claim difficult to defend.

Burns provides meaningful counterevidence. Against the Cubs on August 30, he allowed three runs, two earned, in 5 2/3 innings, striking out seven and walking one. Cincinnati won 7-5. Chicago’s stronger season offense therefore does not guarantee it will control this particular matchup.

Prediction and betting lean

The selection is Chicago Cubs moneyline (-126), with low confidence and a projected 5-4 Cubs win. Chicago’s broader scoring and run-prevention advantages carry the recommendation; the pitching evidence keeps it cautious.

SportsJaw lists over 8.5 (-120) and under 8.5 (+100). The projected nine runs sit above that threshold, but a narrow score projection alone does not establish value on the over. The moneyline remains the single selection.

Projected score

CHC5

CIN4

Confidencelow
Projected winner Chicago Cubs
Betting lean

Chicago Cubs moneyline (-126)

Sources

  • CoversCubs vs Reds Game Overview, Stats, Injuries, Records - MLB Game on September 18, 2026
  • MLB.comChase Burns against the Cubs | 09/18/2026 | Cincinnati Reds

SportsJaw Cubs vs Reds game preview analysis and predictions incorporate current odds, injury reports, team statistics and market data. Information is updated regularly, but lines and player availability can change. Please confirm current information before wagering. View history of past Cubs vs Reds matchups or learn how our predictions work.