| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Indiana HoosiersINDY | 78 | +150 L | +3.75 (-110) L | O 162 (-110) W U 162 (-110) L |
| Louisville CardinalsLOUIS | 87 | -178 W | -3.75 (-110) W |
Louisville Cardinals defeated Indiana Hoosiers 87-78
Louisville Cardinals defeated Indiana Hoosiers 87-78 on December 6, 2025, a 9-point decision in the series. Louisville Cardinals' strongest period was the 1st half, when it outscored its opponent 41-27. Against SportsJaw's recorded Indiana Hoosiers +3.75 (-110) spread, Louisville Cardinals covered, while the 165 combined points finished over the recorded total of 162.
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