| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Notre Dame Fighting IrishNOTRD | 37 | -480 W | -13 (-110) W | O 55 (-110) L U 55 (-110) W |
| Pittsburgh PanthersPITT | 15 | +370 L | +13 (-110) L |
Notre Dame Fighting Irish defeated Pittsburgh Panthers 37-15
Notre Dame Fighting Irish defeated Pittsburgh Panthers 37-15 on November 15, 2025, a 22-point decision in the series. Notre Dame Fighting Irish's strongest period was the 1st quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Notre Dame Fighting Irish -13 (-110) spread, Notre Dame Fighting Irish covered, while the 52 combined points finished under the recorded total of 55.
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