Carolina Panthers versus San Francisco 49ers Head-to-head history

Scores, recaps and recorded betting results from the five most recent meetings in SportsJaw history.

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Nov 24, 2025	Score	Moneyline	Spread	Game total
Carolina PanthersCAR	9	+305 L	+7.5 (-110) L	O 49 (-110) L U 49 (-110) W
San Francisco 49ersSF	20	-395 W	-7.5 (-110) W	O 49 (-110) L U 49 (-110) W

San Francisco 49ers defeated Carolina Panthers 20-9

San Francisco 49ers defeated Carolina Panthers 20-9 on November 24, 2025, a 11-point decision in the series. San Francisco 49ers' strongest period was the 1st quarter, when it outscored its opponent 7-0. Against SportsJaw's recorded Carolina Panthers +7.5 (-110) spread, San Francisco 49ers covered, while the 29 combined points finished under the recorded total of 49.

Team	1	2	3	4	T
Carolina Panthers	0	3	6	0	9
San Francisco 49ers	7	3	7	3	20

Oct 9, 2022	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	37	-258 W	-6 (-110) W	O 39.5 (-110) W U 39.5 (-110) L
Carolina PanthersCAR	15	+215 L	+6 (-110) L	O 39.5 (-110) W U 39.5 (-110) L

San Francisco 49ers defeated Carolina Panthers 37-15

Team	1	2	3	4	T
San Francisco 49ers	7	10	7	13	37
Carolina Panthers	0	3	9	3	15

Oct 27, 2019	Score	Moneyline	Spread	Game total
Carolina PanthersCAR	13	+180 L	+4.5 (-110) L	O 40.5 (-110) W U 40.5 (-110) L
San Francisco 49ersSF	51	-210 W	-4.5 (-110) W	O 40.5 (-110) W U 40.5 (-110) L

Carolina Panthers versus San Francisco 49ers Head-to-head history

Last five meetings

San Francisco 49ers defeated Carolina Panthers 20-9

Carolina Panthers versus San Francisco 49ers Head-to-head history

Last five meetings

San Francisco 49ers defeated Carolina Panthers 20-9

San Francisco 49ers defeated Carolina Panthers 37-15

San Francisco 49ers defeated Carolina Panthers 51-13

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