Chicago Bears versus San Francisco 49ers Head-to-head history

Dec 28, 2025	Score	Moneyline	Spread	Game total
Chicago BearsCHI	38	+185 L	+4 (-110) P	O 51.5 (-110) W U 51.5 (-110) L
San Francisco 49ersSF	42	-220 W	-4 (-110) P

San Francisco 49ers defeated Chicago Bears 42-38

San Francisco 49ers defeated Chicago Bears 42-38 on December 28, 2025, a 4-point decision in the series. San Francisco 49ers' strongest period was the 2nd quarter, when it outscored its opponent 14-7. Against SportsJaw's recorded Chicago Bears +4 (-110) spread, the spread pushed, while the 80 combined points finished over the recorded total of 51.5.