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NFL picks›Indianapolis Colts vs San Francisco 49ers predictions

IndianapolisColtsVSSan Francisco49ers

Upcoming odds, recent results, and verified experts who have performed best when these teams take the field.

SportsJaw’s stored game records date back to 2015. Game history below covers the last 5 years.

Head-to-head history

Last 5 years: head-to-head results

2 final results in the last 5 years of SportsJaw history

Dec 22, 2025
San Francisco 49ers48Indianapolis Colts27Final
Oct 24, 2021
Indianapolis Colts30San Francisco 49ers18Final
Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

1HopkinspicksWeighted grade38+$1,009 · 2 picks2JoeThomasWeighted grade36+$1,159 · 2 picks3MrshinyWeighted grade32+$967 · 2 picks
RankHandicapperGradeProfit
4Moneymouth30+$1,0095AdrianMariucci30+$9096

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.

Dawhiz
30
+$909
7Johnmizner30+$909
8Jw30+$909
9Nutinbutlocks29+$909
10Flyigglesfly28+$909