Detroit Lions vs Arizona Cardinals Predictions October 11, 2026
The Detroit Lions are projected to beat the Arizona Cardinals 28-24, with their efficient passing offense and productive pass rush providing the strongest matchup advantages. Arizona’s opportunity against Detroit’s vulnerable tight-end coverage makes a comfortable road win less certain. The supplied Lions -5.5 (-110) price is a Pass, as is the 51.5 total; the official betting recommendation is Pass.
Detroit Lions vs Arizona Cardinals prediction and best bet
Detroit is the pick to win this Week 5 matchup, but Arizona has enough of a matchup opening to make laying 5.5 points uncomfortable. Jared Goff’s interception-free first three games and Detroit’s pressure production favor the Lions. Their struggles defending tight ends give the Cardinals a plausible way to keep the margin close.
The best betting decision is Pass. Detroit’s early results make a persuasive case for the winner, yet the difference between winning and covering matters here. The statistical evidence covers the first three games, and the injury reports concern Week 4. Those limits temper the case for a Week 5 spread wager.
Odds, game time and how to watch
Game time: Sunday, October 11, 2026, at 1:25 p.m. local Arizona time, 4:25 p.m. Eastern, in Week 5 of the 2026 NFL season.
Venue: State Farm Stadium, Glendale, Arizona.
Broadcast: FOX.
Recent form: Detroit entered Week 4 at 2-1 following a 31-24 home victory over the New York Jets. Arizona scored 30 points in its September 27 loss at San Francisco.
SportsJaw odds: Detroit Lions -5.5 (-110), Arizona Cardinals +5.5 (-110). Moneyline: Detroit -245, Arizona +200. Total: Over 51.5 (-113), Under 51.5 (-108).