Review MLB picks, odds and scores for September 25, 2026. Click a matchup to view picks, writeups and consensus picks on every game. Post and track your own picks to prove your betting acumen to the world.
| Date & time | Matchup | Spread | Moneyline | Total | Predictions |
|---|---|---|---|---|---|
Baltimore OriolesNew York Yankees | +1.5 (-210)-1.5 (+175) | +115-138 | O 6.5 (-115)U 6.5 (-105) | Predictions: Baltimore Orioles vs New York Yankees prediction | |
Chicago CubsBoston Red Sox |
-116-102 |
O 6.5 (-110)U 6.5 (-110) |
Predictions: Chicago Cubs vs Boston Red Sox prediction |
Tampa Bay RaysPhiladelphia Phillies | +1.5 (-165)-1.5 (+140) | +146-163 | O 6.5 (-115)U 6.5 (-105) | Predictions: Tampa Bay Rays vs Philadelphia Phillies prediction |
Pittsburgh PiratesDetroit Tigers | -1.5 (+160)+1.5 (-185) | -109-110 | O 8 (+100)U 8 (-120) | Predictions: Pittsburgh Pirates vs Detroit Tigers prediction |
New York MetsWashington Nationals | -1.5 (+125)+1.5 (-150) | -135+113 | O 8.5 (+105)U 8.5 (-125) | Predictions: New York Mets vs Washington Nationals prediction |
Cincinnati RedsToronto Blue Jays | +1.5 (-210)-1.5 (+170) | +116-136 | O 7.5 (-115)U 7.5 (-105) | Predictions: Cincinnati Reds vs Toronto Blue Jays prediction |
Atlanta BravesMiami Marlins | -1.5 (+135)+1.5 (-160) | -125+105 | O 8.5 (+105)U 8.5 (-125) | Predictions: Atlanta Braves vs Miami Marlins prediction |
Cleveland GuardiansKansas City Royals | -1.5 (+125)+1.5 (-145) | -140+120 | O 7.5 (-115)U 7.5 (-105) | Predictions: Cleveland Guardians vs Kansas City Royals prediction |
St. Louis CardinalsMilwaukee Brewers | +1.5 (-140)-1.5 (+120) | +150-175 | O 8 (-115)U 8 (-105) | Predictions: St. Louis Cardinals vs Milwaukee Brewers prediction |
Colorado RockiesChicago White Sox | +1.5 (-112)-1.5 (-101) | +190-225 | O 8 (-115)U 8 (-105) | View picks: Colorado Rockies vs Chicago White Sox prediction |
Texas RangersMinnesota Twins | -1.5 (+155)+1.5 (-185) | -110-110 | O 7.5 (-115)U 7.5 (-105) | Predictions: Texas Rangers vs Minnesota Twins prediction |
Arizona DiamondbacksSan Diego Padres | +1.5 (-200)-1.5 (+170) | +114-133 | O 7.5 (-105)U 7.5 (-117) | View picks: Arizona Diamondbacks vs San Diego Padres prediction |
Houston AstrosOakland Athletics | -1.5 (+100)+1.5 (-120) | -172+144 | O 8.5 (-110)U 8.5 (-110) | Predictions: Houston Astros vs Oakland Athletics prediction |
Los Angeles AngelsSeattle Mariners | +1.5 (-200)-1.5 (+170) | +112-132 | O 7 (+100)U 7 (-120) | Predictions: Los Angeles Angels vs Seattle Mariners prediction |
Los Angeles DodgersSan Francisco Giants | -2.5 (-120)+2.5 (+100) | -375+300 | O 7.5 (+110)U 7.5 (-130) | Predictions: Los Angeles Dodgers vs San Francisco Giants prediction |
