Arizona Diamondbacks vs San Diego Padres Predictions Today: Brandon Pfaadt vs Casey Mize
The Arizona Diamondbacks are projected to beat the San Diego Padres 4-3 on September 25. Brandon Pfaadt’s strong results against San Diego and recent control give Arizona a slight pitching advantage if Casey Mize starts. With the Padres starter still unconfirmed officially, plus San Diego’s stronger home record and bullpen ERA, the supplied prices produce no actionable wager. The official recommendation is Pass.
Arizona Diamondbacks vs San Diego Padres prediction and best bet
Arizona is the pick to win 4-3, with low confidence. Pfaadt has allowed no earned runs in two starts against San Diego this season, and his six walks across his last seven appearances offer a useful foundation for another competitive outing. Mize’s recent struggles would strengthen Arizona’s case if he takes the mound.
The betting decision is Pass. Covers lists Mize, but MLB’s probable-pitchers page leaves San Diego’s starter to be announced. That uncertainty matters when weighing Arizona +115 against San Diego -135. The Padres also bring a 49-29 home record and the lower bullpen ERA. Arizona gets the narrow forecast advantage without earning an official wager.
Odds, game time and how to watch
Game: Arizona at San Diego, 2026 MLB regular season. First pitch: Friday, September 25, at 9:40 p.m. ET. Venue: Petco Park.
Records: Arizona 85-74 overall, 40-38 away; San Diego 89-70 overall, 49-29 home.
Starters: Arizona right-hander Brandon Pfaadt. Covers lists right-hander Casey Mize for San Diego; MLB’s probable-pitchers page lists the Padres starter as to be announced.
SportsJaw moneylines: Arizona +115; San Diego -135.