Denver Broncos vs Arizona Cardinals Predictions October 25, 2026
The Denver Broncos will beat the Arizona Cardinals, Broncos 23, Cardinals 17, with their pressure and takeaway production providing the strongest matchup advantage against an offense struggling to sustain possessions. Confidence is low because Denver’s victories have stayed close and Arizona’s recent injury news concerns its preceding game. Neither Denver -5.5 nor the 45.5 total offers enough demonstrated value for an official wager.
Denver Broncos vs Arizona Cardinals prediction and best bet
Denver gets the pick because its defense has shown a productive combination of quarterback pressure and takeaways. Arizona’s reported trouble avoiding three-and-outs beyond opening drives gives that strength a relevant target. The forecast favors the Broncos to force enough stalled possessions to win.
The official SportsJaw best bet is Pass. Picking Denver to finish ahead is easier than backing it to cover -5.5 (-110). Its close victories leave a narrow margin for spread bettors, while Arizona’s offensive concerns make taking +5.5 (-110) an uncomfortable alternative. The total deserves its own assessment.
Odds, game time and how to watch
Game: Denver Broncos at Arizona Cardinals, Oct. 25, 2026, during the 2026 NFL season.
Venue: State Farm Stadium in Glendale, Arizona.
Broadcast: CBS.
SportsJaw odds: Denver Broncos -5.5 (-110); Arizona Cardinals +5.5 (-110). Moneyline: Denver Broncos -254; Arizona Cardinals +204. Total: Over 45.5 (-110); Under 45.5 (-110).
SportsJaw moneyline: Denver -250; Arizona +200.
SportsJaw total: Over 45.5 (-110); Under 45.5 (-110).